H300 — Fatal if swallowed
The GHS hazard statement for acute toxicity, oral, categories 1 and 2. Here is what it means, the label elements that travel with it, and the substances that carry it.
At a glance
| Official statement | Fatal if swallowed. |
| Hazard class | Acute toxicity, oral |
| Category | Categories 1 and 2 |
| Signal word | Danger |
| Pictogram |  GHS06 — Skull and crossbones |
What it means
Serious harm — up to and including death — from swallowing a single dose or several doses within 24 hours. Categories 1 (most severe) onward are set from acute toxicity estimates (ATE) per GHS Chapter 3.1.
Precautionary statements paired with H300
When the engine writes SDS Section 2 or a container label for a product carrying H300, these are the P-codes it assigns, in the official Annex 3 groups:
| Prevention | P264 | Wash hands and exposed skin thoroughly after handling. |
| P270 | Do not eat, drink or smoke when using this product. | |
| Response | P301 | IF SWALLOWED: rinse mouth. Do NOT induce vomiting. |
| P310 | Immediately call a POISON CENTER or doctor. | |
| P321 | Specific treatment (see supplemental first-aid instructions on this label). | |
| Storage | P405 | Store locked up. |
| Disposal | P501 | Dispose of contents/container in accordance with local/regional/national/international regulations. |
Substances that carry H300
147 of the 4,225 substances in our database carry H300 when classified in pure form — recognizable examples:
- (R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone — CAS 5543-58-8
- (S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone — CAS 5543-57-7
- [(dimethylsilylene)bis((1,2,3,3a,7a-η)-1H-inden-1-ylidene)dimethyl]hafnium — CAS 137390-08-0
- 1-(3,4-dichlorophenylimino) thiosemicarbazide — CAS 5836-73-7
The engine writes these for you.
When SDS HQ authors an SDS or a container label, it assigns the hazard statements, signal word, pictograms, and precautionary statements from these same tables — automatically, with the calculation shown.