GHS REFERENCE / H-CODES / H335

H335 — May cause respiratory irritation

The GHS hazard statement for specific target organ toxicity, single exposure, category 3 (respiratory tract irritation). Here is what it means, the label elements that travel with it, and the substances that carry it.

At a glance

Official statementMay cause respiratory irritation.
Hazard classSpecific target organ toxicity, single exposure
CategoryCategory 3 (respiratory tract irritation)
Signal wordWarning
PictogramGHS07 HarmfulGHS07 — Exclamation mark

What it means

Effects on a specific organ or body system from a single exposure. Categories 1 and 2 cover significant organ damage (proven or presumed vs. suspected); Category 3 covers transient effects — airway irritation or drowsiness/dizziness — that pass after exposure ends.

Precautionary statements paired with H335

When the engine writes SDS Section 2 or a container label for a product carrying H335, these are the P-codes it assigns, in the official Annex 3 groups:

PreventionP261Avoid breathing dust/fume/gas/mist/vapors/spray.
P271Use only outdoors or in a well-ventilated area.
ResponseP304IF INHALED:
P312Call a POISON CENTER or doctor if you feel unwell.
P340Remove person to fresh air and keep comfortable for breathing.
StorageP403Store in a well-ventilated place.
P405Store locked up.
DisposalP501Dispose of contents/container in accordance with local/regional/national/international regulations.

Substances that carry H335

253 of the 4,225 substances in our database carry H335 when classified in pure form — recognizable examples:

  • glutaral — CAS 111-30-8
  • tetrahydrofuran — CAS 109-99-9
  • (±)-butan-2-ol — CAS 15892-23-6
  • (1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)] diacrylate — CAS 42978-66-5

Same hazard class: H336 · H370 · H371

Reference information, not legal or professional advice. Statement texts and allocations follow GHS Rev 9 / 29 CFR 1910.1200 Appendix C as implemented by our classification engine; the regulatory text and agency practice control. Claims last reviewed July 23, 2026.

The engine writes these for you.

When SDS HQ authors an SDS or a container label, it assigns the hazard statements, signal word, pictograms, and precautionary statements from these same tables — automatically, with the calculation shown.

Start freeHow classification works